Advantages and Disadvantages of HIFU ceramics transducer

Compared with surgery, HIFU ceramic transducer for machine is non-invasive and has few complications. Compared with radiotherapy, H IFU can obtain a therapeutic dose in one irradiation, and can also repeat the treatment of residual lesions or locally recurring lesions. The use of H IFU does not exclude traditional treatment methods, and has synergistic or sensitizing effects with radiotherapy and chemotherapy, so it can be used in combination. H IFU treatment does not depend on tissue type, and special tumors that are unlikely to be treated can be inactivated in the H IFU high temperature sound field, which is better than H IFU in radiotherapy and chemotherapy. others believe that HIFU ceramics for lasers medical can not only perform three-dimensional conformal treatment, but also safely destroy tumors, and it has no damage to blood vessels above small arteries. It is suitable for the treatment of adjacent blood vessels adjacent to tumors, so that tumors adjacent to large blood vessels can be safely treated. In the early treatment of H IFU in vitro tumors, Visioli et al. confirmed that treatment-related symptoms rarely occurred in the treatment of liver, kidney and prostate. The most serious symptoms were only moderate (2 / 14). Vallancien reported that in the treatment of superficial bladder tumors, there were no complications other than skin burns in 2 patients (2 / 20). More recent reports suggest that local pain, temporary fever and skin burns are the most common complications.

There is also some data from the treatment of prostate cancer with HIFU beauty sensor transducer. Complications are similar to surgery and radiofrequency treatment. The most serious complication is due to rectal urethral leakage due to damage to the rectal wall. With the improvement of the safety performance of instruments and equipment (such as the cooling of the rectal wall), the above complications generally do not occur. It has also been reported that in the treatment, there is no intention to damage the organs adjacent to the target tumor, repeated ablation causes tissue necrosis, and abscess formation after bacterial invasion, but the incidence of these complications is less than 1%. In contrast, Wang Wei et al reported that patients with bone tumor treatment had complications such as lung metastasis, local recurrence, nerve injury, pathological fracture and skin injury, and the overall incidence was 36%. Strict control of indications and standardized procedures can reduce the damage caused by treatment.

Intraoperative temperature monitoring: T1 relaxation time, water molecule diffusion constant, and proton resonance frequency shift in MR imaging are linearly related to temperature changes. This feature can be used to monitor changes in tumor internal temperature during focused ultrasonic transducer treatment and can depict H. Temperature distribution of various parts of deep organs during IFU treatment. The continuity of monitoring and the reproducibility of imaging make temperature monitoring possible during H IFU treatment. However, MR I temperature measurement is susceptible to respiratory motion, long imaging time, high price, compatibility with H IFU equipment and high environmental requirements, which limits its application. In the United States, MR temperature measurement is limited to large research centers. It is urgently needed to explore economic, real-time and non-invasive methods of temperature measurement. Maass et al. attempt to estimate the temperature of tissue using the principle that tissue temperature changes affect ultrasound echoes, but are also subject to many conditions. Qian Zuwen et al. used ultrasonic inversion to measure the focal temperature during H IFU. The results of animal experiments showed that the temperature measurement accuracy was about ±3 °C. If the clinical application is successful, it will have a profound impact on the development of treatment standards and the popularization of 2Mhz HIFU ceramic transducer.

As a new treatment, HIFU has been successfully applied to both tumor and non-tumor treatments, and has shown its unique advantages. This treatment can prolong life, relieve pain and improve quality of life. With the accumulation of a large number of cases in clinical applications and the resolution of non-destructive temperature measurement, H IFU treatment methods will be continuously improved.At present, the domestic manufacturers of HIFU piezoceramics transducer treatment machines mainly include Chongqing Haifu (H IFU) Technology Co., Ltd., Beijing Yuande Biomedical Engineering Co., Ltd., and Shanghai Aishen Technology Development Co., Ltd. The HIFU Tumor Surgery Center was established by the IUFU Tumor Surgery Center. The HIFU technique was applied to the preoperative treatment of solid tumors. A large amount of data showed that the surgical resection rate of solid tumors was improved and the number of surgical resections was reduced. Tumor cell dissemination caused by intraoperative operation should improve the long-term therapeutic effect of tumor patients.